Concept: Gentamicin in the CH10 vocabulary

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Concept URI	https://kodlistor.miljodatasamverkan.se/def/vocabulary/KemBioFys_PARAMETERNAMN/CH10/130
Preferred label	Gentamicin
Definition
Notation	CH10/130
Status	Valid
Status Modified	2025-05-28
Accepted Date	2025-05-28
Not Accepted Date
Alternative label	Gentamicin [en]
Validity	Valid
Systematic name (IUPAC)	General formula: (3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-Diamino-3-{[(2R,3R,6S)-3-amino-6-[(1R)-1-(methylamino)ethyl]oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol; Gentamycin C1: (1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-β-L-lyxo-heptopyranoside; Gentamycin C1a: (1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranoside; Gentamycin C2: (1R,2S,3R,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2,6-diamino-2,3,4,6,7-pentadeoxy-α-D-ribo-heptopyranoside
CAS-Nr	1403-66-3
EC-Nr	215-765-8
Huvud-grupper	Läkemedel
Sub-grupper	Aminoglykosider
Användningsområde/Egenskaper	Antibiotika/"A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1(subA), obtained from Micromonospora purpurea and related species." (Toxnet) "Gentamicin is composed of a number of related gentamicin components and fractions which have varying degrees of antimicrobial potency. The main components of gentamicin include members of the gentamicin C complex: gentamicin C1, gentamicin C1a, and gentamicin C2 which compose approximately 80% of gentamicin and have been found to have the highest antibacterial activity. Gentamicin A, B, X, and a few others make up the remaining 20% of gentamicin." (Wikipedia)